How to Transform Negative Self-Talk into Positivity for Healing Chronic Disease. The bad news: Negative self-talk can be very damaging to your health. The good news: You can quickly learn to transform negative self-talk into positive thinking that can actively help you in healing chronic diseases, from diabetes to cancer. What is negative self-talk? This is the term for the kind of demeaning, insulting, or belittling internal messages that we give ourselves when we are frustr